The Human Effect Matrix summarizes human studies to tell you what effects turmeric, echinacea, saw palmetto, milk thistle, Ginkgo Biloba. Chiang HM, Fang SH, Wen KC, et al. The tuberous root varies in size depending on soil condition, but may weigh as much as 100 kg. Medically reviewed by Drugs.com. Pueraria lobata. Pueraria mirifica is sometimes used as an anti-aging supplement or as a natural remedy for menopausal symptoms such as hot flashes and vaginal dryness. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. manufacturers, food companies, and industry funders. J Ethnopharma col 1-4-2005;96(1-2):133-138. Because of pueraria's estrogen-like effect, use with caution in patients with asthma, diabetes mellitus, epilepsy, migraine, or systemic lupus erythematosus. Each member of our research team is required to have no conflicts of interest, including with supplement We have a strict editorial process. Radix Pueraria lobata (RP) has been reported to prevent obesity and improve glucose metabolism; however, the mechanism responsible for these effects has not been elucidated. May affect concentration of these medications. P. mirifica may greatly alter the length of menstrual cycles and suppress ovulation by reducing serum levels of gonadotropins. Phytoestrogens have estrogen-like effects. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. If using any pharmaceuticals or drugs given to you by a doctor or received with a prescription, you must consult with the doctor in question or an equally qualified Health Care Professional prior to using any nutritional supplementation. each outcome. Kudzu (Pueraria lobata) is one of the earliest medicinal plants used in traditional Chinese medicine. Directions: Adults take 1 capsule daily with food or as directed by your doctor and/or qualified health professional. View abstract. Menopausal symptoms; general female reproductive health; support of bone, hair, and fingernails; sexual longevity including vaginal lubrication; and enhanced breast size. The report provides an understanding of the global Pueraria Lobata Root Extract industry competitors, … Our independent, unbiased approach reveals what works (and what's a waste of time and money). mirifica also had an estrogenic effect on a human HepG2 hepatoma cell line that contained an estrogen receptor and a luciferase reporter gene; this evidence indicates that metabolic activation of P. mirifica promotes estrogenic activity.Lee 2002 Another study also documents that estrogenic activity may result from metabolic activation of liver enzymes.Cherdshewasart 2008, The proposed mechanism of action involves strong competitive binding of the plant's phytoestrogens to ER-alpha and/or synthesis suppressor of ER-alpha.Cherdshewasart 2007, Pretreatment of rats with P. mirifica (1,000 mg/kg body weight per day tuberous root powder) resulted in decreased virulence of rat mammary tumor development from 7,12-dimethylbenz(a)anthracene (7,12-DMBA). The experimental diet was made by adding powdered Pueraria root extract (0.2% w/w) to AIN-93M, a phytoestrogen-free diet (see Reeves et al, 1993 for a full description of this diet). followed by specifically-applicable references. The team includes nutrition researchers, registered dietitians, physicians, and pharmacists. In rabbits, P. mirifica improved endothelial function through a nitric oxide pathway, decreased contractile responses to norepinephrine, and increased responses to estradiol. the roots and flowers of kudzu, Radix and Flos puerariae, respectively, have been used to treat alcohol abuse safely and effectively in China for more than a millennium. Commercial manufacturers suggest a dosage of 250 mg of active ingredients from the root orally every morning and evening. Overall activity was more potent in female rats than in male rats. Commercial products are available as topical creams, gels, and soaps, or in oral capsule and tablet dosage forms.Sookvanichsilp 2008, Malaivijitnond 2006, Chansakaow 2000, Liang 2000, Roufs 2007, Yagi 2007, Tehara 2006, Liu 2005, Konoike 2006, Ishiwatari 2003 Some clinical studies used 200 to 400 mg extract from root or tuber orally per day. Pueraria Mirifica is a tropical herb that originated in Thailand which is known to have highest compound than its family plant while Pueraria Lobata or Kudzu root has its own origin in China. Search by keywords . VERY HIGH means that most of the scientific research agrees. Information tailored to you, updated every month. for this page. Pueraria Mirifica (same genera, different herb), Japanese Knotweed (also called Kudzu), Angelica dahurica (enhances absorption of Puerarin from Pueraria Lobata), Savlia Miltiorrhiza (Danshen) for anti-inflammatory purposes. J Pharmacol Sci 2004;96:420-7. Anti-aging Agents (3) Anti-inflammatories (3) Anti-wrinkle Agents (1) Antimicrobials (1) Antioxidants (5) View abstract. No alterations in Apolipoprotein B have been noted, No significant influence of Pueraria lobata on circulating estrogen levels (although it itself may be a phytoestrogen; weak). It is applied in food field, pueraria isoflavones can lower blood pressure 2. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Prasain JK, Peng N, Rajbhandari R, Wyss JM. Studies in mice found that P. mirifica does not affect male fertility or the hypothalamus-pituitary-testis axis.Jaroenporn 2006 The testis, epididymis, and seminal vesicle all had normal histopathology in P. mirifica -treated male mice. Results indicated that P. lobata exhibited high PTP1B inhibitory activity with IC 50 of … If undergoing medical therapies, then consult with your respective Therapist or Health Care Professional about possible interactions between your Treatment, any Pharmaceuticals or Drugs being given, and possible nutritional supplements or practices hosted on Examine.com. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. May decrease serum free thyroxine concentrations. Become an Examine.com member to get access to the latest research. Click here to see the full set of references The team includes nutrition researchers, registered Examine.com is intended to be used for educational and information purposes only. Because of its phytoestrogen-like effects, use pueraria with caution if diagnosed with an estrogen-dependent neoplasia, pulmonary embolism, liver dysfunction or disease, or anemia. Becoming a member also unlocks our study database of 400+ supplements and their effects on 600+ health outcomes. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. iCrowdNewswire Oct 15, 2020 9:15 AM ET. Ann Dermatol. View abstract. 12. The mechanism underlying anti-obesity effect of RP was investigated in high-fat diet (HFD) induced obese mice and skeletal muscle cells (C2C12). Efficacy and Safety of Pueraria lobata Extract in Gray Hair Prevention: A Randomized, Double-Blind, Placebo-Controlled Study. Theoretically, drug interactions may occur with the following: May increase pharmacologic and toxicologic effects. It is unsure if this is near the optimal dosage or not. Habitat: Kudzu is native to India, China, and Japan. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Supplement Facts. Our evidence-based analysis on pueraria lobata features "Pueraria lobata," Examine.com, published on 30 September 2013, last updated on This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. Some of the isoflavonoids in P. mirifica had antioxidant activity similar to that of alpha tocopherol or vitamin E.Cherdshewasart 2008P. The plant caused no changes in lipid profile or liver enzymes.Wattanapitayakul 2005 In male and female gonadectomized rats, P. mirifica had estrogen-like activity and affected accessory sex organs. Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. A small (n= 52) clinical study evaluated oral P. mirifica at 25 and 50 mg over 6 months in relieving menopausal symptoms, and reported efficacy for both doses. The estrogenic activity of kudzu and the cardioprotective effects of its constituent puerarin are also under investigation, but clinical trials are limited. No significant alterations in luteinizing hormone has been detected with pueraria lobata ingestion. Pueraria lobata has on your body, how much evidence Study: The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice. All factual claims are Pueraria lobata – Kudzu New! Most commercial products containing pueraria are available as rejuvenating, antiaging, or skin-lightening creams or gels, as beauty soaps, or as capsules or tablets for increasing appetite, enlarging breasts, modulating hair growth or regrowth, and other rejuvenating purposes. Examine.com and its Editors do not advocate nutritional supplementation over proper medical advice or treatment and this sentiment will never be expressed through pages hosted under Examine.com. The main plant sources of Pueraria extract are the dried roots of Pueraria Lobata Willd Ohwi or Pueraria Thomsonii Bentn, which are commonly known as “Pueraria Lobata”. Another component, known as PE-D, affected the growth in a dose-dependent and time-dependent manner on some breast cancer cell lines (MCF-7, MDAMB-231), and on the growth of ovarian (2774) and cervical cancer cells (HeLa).Baek 2003, Jeon 2005 The estrogenic effect of some components in P. mirifica has been compared with estradiol, a major estrogen in humans.Jeon 2005, Cherdshewasart 2008 The rank order of phytoestrogen potency is: deoxymiroestrol; miroestrol; 8-prenylnaringenin; coumestrol; genistein/equol; daidzein; resveratrol.Matsumura 2005P. Click here The main ingredient of Pueraria extract. The medical literature documents the plant's use primarily for menopause, but also for cancer and osteoporosis. A standardized kudzu extract (NPI-031) reduces alcohol consumption in nontreatment-seeking male heavy drinkers. Commercial manufacturers suggest 250 mg (root or tuber) by mouth every morning and evening. 13. In postmenopausal osteoporotic monkeys oral administration of P. mirifica improved both bone quality and quantity.Kittivanichkul 2016. The length of the menstrual cycle increased in monkeys treated with P. mirifica 10 and 100 mg/day of root extract and disappeared completely in monkeys treated with root extract 1,000 mg/day. During the posttreatment period, only monkeys treated with P. mirifica 10 and 100 mg/day of extract recovered from the changes in menstrual cycle length and hormone levels.Trisomboon 2005 Other studies document similar activity for the P. mirifica 1,000 mg/day dose of Trisomboon 2004 root extract and the direct correlation in dose with gonadotrophin levels.Trisomboon 2006, The plant had a dose-dependent estrogenic effect on rat vaginal cornification.Cherdshewasart 2007P. Select one or more newsletters to continue. Pueraria Lobata Root Extract Applications: 1. 2013 Mar;226(1):65-73. Our evidence-based analysis on pueraria lobata features 32 unique references to scientific papers. HIGH or   The root of the plant contains compounds classified as phytoestrogens, meaning that they have estrogen-like effects. The plant genus Pueraria is named after the Swiss Professor M. N. Pueraria (1766-1845). Gluten Free! 32 unique references to scientific papers. Kudzu Root Extract. The ethanol extract had antiproliferative effects on breast cancer cell lines MCF-7, ZR-75-1, MDA-MB-231, SK-BR-3, and Hs578T. It is perhaps better known by its Japanese name: kudzu. Join over 250,000 people who have learned about effective versus overrated supplements, tips for buying supplements, and how to combine supplements for safety and efficacy. Other name:kudzu root extract,Kudzuvine Root extract,pueraria lobata extract Plant Origin: Pueraria lobata(Willd.)Ohwi . Get our free 5-day course on the essentials of supplementation. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. A comparative study on aqueous root extracts of Pueraria thomsonii and Pueraria lobata by antioxidant assay and HPLC fingerprint analysis. This page features 32 references. This information is not specific medical advice and does not replace information you receive from your health care provider. Scientific research does not always agree. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. ITM: Pueraria: Source of Important Isoflavones, by Subhuti Dharmananda, Ph.D., Director, Institute for Traditional Medicine, Portland, Oregon. The latest published report namely Global Pueraria Lobata Root Extract Market Growth 2020-2025 added by MarketandResearch.biz offers an insightful take on the historical data of the market and predictions for 2020 to 2025 time-period. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. Fu-Liang X, Xiao-Hui S, Lu G, Xiang-Liang Y, Hui-Bi X. Puerarin protects rat pancreatic islets from damage by hydrogen peroxide. The benefits of Pueraria are seemingly endless; some people use it to alcoholism, heart and circulatory problems, upper respiratory problems, and skin problems. The lone study on Kudzu root used a product containing 100mg of isoflavone equivalents, which appeared to be slightly effective for promoting cognition in postmenopausal women. Puerarin acts through brain serotonergic mechanisms to induce thermal effects. Background: the … Toxicol Appl Pharmacol 2005;209:263-8. We initiated the project by searching the possible target of the Pueraria lobata root extract (P. lobata).We conducted the IC 50 assays of P. lobata on the four diabetes-related proteins: PTP1B, TCPTP, SHP-2 and DPP-4. The researchers suggest 1 mg of P. mirifica is equivalent to 0.52 to 0.75 mcg of ethinyl estradiol.Virojchaiwong 2011, Similar to findings in monkeys,Jaroenporn 2014 a randomized clinical study (n=82) reported P. mirifica gel to be effective in improving signs of vaginal atrophy and restoring vaginal epithelium at 6 and 12 weeks, but to a lesser extent than conjugated estrogen cream.Suwanvesh 2017, In small clinical trials, the administration of P. mirifica crude extract improved hot flushes, frustration, sleep disorder, skin dryness, high blood cholesterol, amenorrhea, and other menopause-related symptoms in women. 32 unique references to scientific papers. The tuberous roots of P. mirifica primarily contain the active component miroestrol and its derivative, deoxymiroestrol.Chansakaow 2000 The tuberous roots of P. mirifica also contain daidzin, daidzein, genistin, genistein, puerarinIngham 1986 mirificoumestan, kwakhurinIngham 1986, Tahara 1987 coumestrolIngham 1988 mirificin, and 2 steroids, estrone and estriol.Sookvanichsilp 2008, Ingham 1986, Ingham 1989, Chansakaow 2000 The manufacture and synthesis of miroestrol is documented.Corey 1993, Ishikawa 2006 Deoxymiroestrol was isolated and identified as the most active phytoestrogen of the plant.Cherdshewasart 2004, Sookvanichsilp 2008, Ishikawa 2001. This page features 32 references. Type 2 diabetes mellitus is a fast-growing epidemic affecting people globally. Scientific Name(s): Pueraria mirifica Airy Shaw et. Bonus: unlock the supplement Human Effect Matrix and all health topics on Examine.com. No significant influence on circulating LDL-C has been noted with supplementation. This page is regularly updated, to include the most recently available clinical trial evidence. This product may be unsafe when used before surgery or other medical procedures. Kudzu (Pueraria lobata) is one of the earliest medicinal plants used in traditional Chinese medicine. Category. However, there is no literature to support these uses. December 2020; BMC Complementary Medicine and Therapies 20(1) DOI: 10.1186/s12906-020-02998-1. In sex-hormone–deficient male rats, treatment with P. mirifica root powder completely inhibited bone loss in long bones and axial bones. Kudzu is being investigated for its potential use as a therapy for alcoholism; however, sufficient and consistent clinical trials are lacking. Servings per Container: 50. This item: Kudzu Alcohol-Free Liquid Extract, Organic Kudzu (Pueraria lobata) Dried Root Glycerite Hawaii Pharm… $24.95 ($12.48 / 1 Fl Oz) In Stock. there is, and how strong these effects are. Its root is also fast growing, typically reaching 50 pounds or more, and can attain a weight of 400 pounds (about 2/3 of it is water). Psychopharmacology (Berl). Buy Kudzu (Pueraria Lobata) Tincture, Organic Dried Roots Liquid Extract 2 oz on Amazon.com FREE SHIPPING on qualified orders That's why we don’t sell any advertising or supplements. Last updated on Jul 27, 2020. Five-week-old C5BL/6 mice were fed a HFD containing or not … Highest Strength Kudzu liquid extract! The blue-to-purple flowers are composed of 5 petals and bloom from February to March. At Examine.com, our incentives line up with yours — getting unbiased information. mirifica phytoestrogens at a dose of root extract 1,000 mg/day decreased serum parathyroid hormone and calcium levels in aged menopausal monkeys and, thus, may be beneficial in treating bone loss caused by estrogen deficiency.Trisomboon 2004P. dietitians, physicians, and pharmacists. Some clinical studies used 200 to 400 mg (extracted from the root or tuber) by mouth per day. No significant alterations have been noted in follicle-stimulating hormone concentrations following pueraria lobata ingestion. What makes it difference is the amount of its active compound called Phytoestrogen. There was no change in blood cells or liver and renal function.Hosoyama 2007, Muangman 2001. Kudzu liquid extract contains ONLY natural ingredients! Serum FSH, LH, estradiol, progesterone, and immunoreactive-irinhibin were lower in a dose-dependent manner during treatment. 319 pueraria lobata root products are offered for sale by suppliers on Alibaba.com, of which herbal extract accounts for 23%, other extracts accounts for 7%. The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice.
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